SensAmone P5 is a biomimetic peptide that is based on a sea anemone protein which calms sensitive skin and reduces skin irritation.
Sensitive skin is often characterized by an overactivity of the TRPV1 pain receptor. The result is skin that can react strongly to harmless environmental stimuli with itching or even burning and redness.
Scientists have recently discovered a unique protein in the venom of the leathery sea anemone that acts as an inhibitor of the TRPV1 receptor. As the protein is unstable and too large to penetrate the skin, Mibelle Biochemistry has developed a pentapeptide that contains the TRPV1 inhibitor sequence of the sea anemone protein. To ensure improved skin uptake, the peptide was incorporated into a soft sphere carrier system based on shea butter.
Inspired by sea anemone venom technology, SensAmone P5 has been designed as a novel neurocosmetic soothing active.
Inhibition of TRPV1 receptor activation
Instant reduction of skin reactivity following a single application
Reduction of skin sensitivity
In vivo study
In vitro study
- Calms overreactive skin
- Minimizes skin’s response to stress
- Reduces the itching sensation of sensitive skin
INCI (EU/PCPC) Declaration
Pentapeptide-59 (and) Hydrogenated Lecithin (and) Butyrospermum Parkii (Shea) Butter (and) Phenethyl Alcohol (and) Ethylhexylglycerin (and) Maltodextrin (and) Aqua/Water
Recommended Use Level
1 - 2%