SensAmone P5

SensAmone P5

Immediate comfort for sensitive skin

About SensAmone P5

SensAmone P5 is a biomimetic peptide that is based on a sea anemone protein which calms sensitive skin and reduces skin irritation.


Sensitive skin is often characterized by an overactivity of the TRPV1 pain receptor. The result is skin that can react strongly to harmless environmental stimuli with itching or even burning and redness.

Scientists have recently discovered a unique protein in the venom of the leathery sea anemone that acts as an inhibitor of the TRPV1 receptor. As the protein is unstable and too large to penetrate the skin, Mibelle Biochemistry has developed a pentapeptide that contains the TRPV1 inhibitor sequence of the sea anemone protein. To ensure improved skin uptake, the peptide was incorporated into a soft sphere carrier system based on shea butter.

Inspired by sea anemone venom technology, SensAmone P5 has been designed as a novel neurocosmetic soothing active.


60 second pitch of Dr. Fred Zülli

Proven Efficacy

  • Inhibition of TRPV1 receptor activation

  • Instant reduction of skin reactivity following a single application

  • Reduction of skin sensitivity

  • In vivo study

  • In vitro study

Claim Ideas

  • Calms overreactive skin
  • Minimizes skin’s response to stress
  • Reduces the itching sensation of sensitive skin

INCI (EU/PCPC) Declaration

Pentapeptide-59 (and) Hydrogenated Lecithin (and) Butyrospermum Parkii (Shea) Butter (and) Phenethyl Alcohol (and) Ethylhexylglycerin (and) Maltodextrin (and) Aqua/Water

Recommended Use Level

1 - 2%

Scientific Publications