Harnessing the Power of Transcriptomics: A New Approach to Skin Aging

Skin aging is a complex process, influenced by both internal and external factors. As we age, the functionality of our skin's dermal stem cells, the bedrock of skin health and homeostasis, begins to falter. Understanding the molecular intricacies of skin aging is vital to developing effective anti-aging strategies.

A recent scientific study has shed light on the role of RNA splicing in aging dermal stem cell modulation. Using using primary human dermal stem cells obtained from skin samples of young (< 30y) and aged (>60y) female donors, the study aimed to understand fundamental changes occurring during aging. The research was sponsored by Mibelle Group and was independently carried out by Curio Biotech, also based in Switzerland.

The authors employed an innovative technique known as bulk RNA barcoding and sequencing (BRB-seq) to identify differentially expressed genes (DEGs) in young and aged dermal stem cells. The results highlighted significant changes in key cellular processes, such as cell proliferation, Extracellular Matrix (ECM) synthesis, and RNA splicing.

An interesting discovery was the role of a natural extract, made up of callus cells and Alpine rose leaf extracts, in influencing RNA splicing in aged dermal stem cells. RNA splicing is a fundamental process in gene expression and cellular function. By modulating this process, the natural extract led to improvements in dermal structure and integrity in vitro.

This study underscores the potential of integrating high-throughput transcriptomics in understanding skin aging and opens new avenues for the development of innovative, sustainable, and effective anti-aging strategies. It also highlights the potential of natural extracts, like callus cells, in promoting skin health and longevity.

The results of this study could potentially pave the way for new anti-aging solutions. The role of botanical extracts in modulating aging dermal stem cells is a promising avenue for further research and development in the cosmetics industry. It's an exciting time for science and skincare enthusiasts alike, as we continue to explore the potential of nature in slowing down the aging process.

The study had been conducted by Julia Baumann, Valentine Vocat, Kathrin Nowak, Fred Zülli, Chennakesava Cuddapah, and Franziska Wandrey. A special thanks goes to our collaborators at Curio Biotech. 

Link to Publication: Bulk RNA Barcode Sequencing Reveals Role of RNA Splicing in Aging Dermal Stem Cell Modulation by a Botanical Extract (mdpi.com)