SensAmone P5

Immediate comfort for sensitive skin

Redness / Sensitive Skin / Wellbeing

Redness / Sensitive Skin / Wellbeing

SensAmone P5 is a biomimetic peptide that is based on a sea anemone protein which calms sensitive skin and reduces skin irritation.

Sensitive skin is often characterized by an overactivity of the TRPV1 pain receptor. The result is skin that can react strongly to harmless environmental stimuli with itching or even burning and redness.

Scientists have recently discovered a unique protein in the venom of the leathery sea anemone that acts as an inhibitor of the TRPV1 receptor. As the protein is unstable and too large to penetrate the skin, Mibelle Biochemistry has developed a pentapeptide that contains the TRPV1 inhibitor sequence of the sea anemone protein. To ensure improved skin uptake, the peptide was incorporated into a soft sphere carrier system based on shea butter.

Inspired by sea anemone venom technology, SensAmone P5 has been designed as a novel neurocosmetic soothing active.



Peptides for the Skin

Peptides consist of amino acids and have the same chemical structure as proteins, but are shorter in length. These protein fragments perform multiple functions in the skin like activating wound healing, activating immune responses and regulating hormonal activities.

These active molecules are beneficial for inter-cellular communication - for example when collagen breaks down, specific peptides are formed to signal to skin cells to build new collagen.

There are many different types of peptides used in cosmetics such as signal peptides, carrier peptides, neurotransmitter inhibitor peptides, and enzyme inhibitor peptides.

Peptides offer a very high biological potency and the spectrum in the fields of cosmetics is continuously growing.

Lab 6
Sens Amone P5 Plant Source
Proven efficacy

In vitro

In vivo

  • Inhibition of TRPV1 receptor activation
  • Instant reduction of skin reactivity following a single application
  • Reduction of skin sensitivity
  • Calms overreactive skin
  • Minimizes skin’s response to stress
  • Reduces the itching sensation of sensitive skin
INCI (EU/PCPC) Declaration

Pentapeptide-59 (and) Hydrogenated Lecithin (and) Butyrospermum Parkii (Shea) Butter (and) Phenethyl Alcohol (and) Ethylhexylglycerin (and) Maltodextrin (and) Aqua/Water



  • Liquid
  • Water-soluble
  • Without alcohol
  • Preservative-free

Recommended use level

  • 1 – 2 %
More information about SensAmone P5

Find more4 about SensAmone P5 on https://www.ulprospector.com/de/eu/PersonalCare/Detail/2249/348837/Alpine-Rose-Active.

PDF Download
Do you have any question about SensAmone P5?
SensAmone P5_fullwidth